Genetics for understanding and predicting clinical progression in multiple sclerosis.

Published in Revue neurologique

Multiple sclerosis (MS) is a dys-immune disease of the central nervous system with highly variable and unpredictable long-term outcome. In the early 1970s association between HLA alleles and MS was established. Very recently, the power of Genome Wide Association Studies (GWAS) enabled the identification of several loci involved in immune functions ...

Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates

Published in Cell

Structure-function relationships of CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter b...

OBJECTIVES: In the context of the increasing worldwide occurrence of imipenem-resistant Acinetobacter baumannii strains, we investigated a possible porin-mediated mechanism relating to the carbapenem resistance-associated outer membrane protein, CarO. The aim of this study was to determine whether this porin may be a diffusion pathway for carbapene...

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

Published in Proc Natl Acad Sci U S A

IRF8 mutations and human dendritic-cell immunodeficiency.

Published in The New England journal of medicine

The genetic analysis of human primary immunodeficiencies has defined the contribution of specific cell populations and molecular pathways in the host defense against infection. Disseminated infection caused by bacille Calmette-Guérin (BCG) vaccines is an early manifestation of primary immunodeficiencies, such as severe combined immunodeficiency. In...

Msx genes define a population of mural cell precursors required for head blood vessel maturation.

Vessels are primarily formed from an inner endothelial layer that is secondarily covered by mural cells, namely vascular smooth muscle cells (VSMCs) in arteries and veins and pericytes in capillaries and veinules. We previously showed that, in the mouse embryo, Msx1(lacZ) and Msx2(lacZ) are expressed in mural cells and in a few endothelial cells. T...

Pathologic calcification of adult vascular smooth muscle cells differs on their crest or mesodermal embryonic origin

International audience

Ambivalent role of the innate immune response in rabies virus pathogenesis.

Published in Journal of virology

The neurotropic rabies virus (RABV) has developed several evasive strategies, including immunoevasion, to successfully infect the nervous system (NS) and trigger a fatal encephalomyelitis. Here we show that expression of LGP2, a protein known as either a positive or negative regulator of the RIG-I-mediated innate immune response, is restricted in t...

CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope

Published in PLoS Pathog

Phage display of combinatorial peptide libraries: application to antiviral research.

Published in Molecules (Basel, Switzerland)

Given the growing number of diseases caused by emerging or endemic viruses, original strategies are urgently required: (1) for the identification of new drugs active against new viruses and (2) to deal with viral mutants in which resistance to existing antiviral molecules has been selected. In this context, antiviral peptides constitute a promising...