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H2B Ubiquitylation Controls the Formation of Export-Competent mRNP.

Vitaliano-Prunier, Adeline Babour, Anna Hérissant, Lucas Apponi, Luciano Margaritis, Thanasis Holstege, Frank C P Corbett, Anita H Gwizdek, Carole Dargemont, Catherine

Histone H2B ubiquitylation is a transcription-dependent modification that not only regulates nucleosome dynamics but also controls the trimethylation of histone H3 on lysine 4 by promoting ubiquitylation of Swd2, a component of both the histone methyltransferase COMPASS complex and the cleavage and polyadenylation factor(CPF). We show that preventi...

Phosphatidylinositol 5-Phosphatase Oculocerebrorenal Syndrome of Lowe Protein (OCRL) Controls Actin Dynamics during Earl... PDF available through Get Fulltext Research

Kuehbacher, Andreas Dambournet, Daphne Echard, Arnaud Cossart, Pascale Pizarro-Cerda, Javier

Listeria monocytogenes is a bacterial pathogen that induces its own entry into a broad range of mammalian cells through interaction of the bacterial surface protein InlB with the cellular receptor Met, promoting an actin polymerization/depolymerization process that leads to pathogen engulfment. Phosphatidylinositol bisphosphate (PI[4,5]P-2) and tri...

The Evolutionary Landscape of Cytosolic Microbial Sensors in Humans PDF available through Get Fulltext Research

Vasseur, Estelle Boniotto, Michele Patin, Etienne Laval, Guillaume Quach, Hélène Manry, Jeremy Crouau-Roy, Brigitte Quintana-Murci, Lluis

Published in The American Journal of Human Genetics

Host-pathogen interactions are generally initiated by host recognition of microbial components or danger signals triggered by microbial invasion. This recognition involves germline-encoded microbial sensors or pattern-recognition receptors (PRRs). By studying the way in which natural selection has driven the evolution of these microbial sensors in ...

Mutations affecting interaction of integrase with TNPO3 do not prevent HIV-1 cDNA nuclear import PDF available through Get Fulltext Research

Cribier, Alexandra Ségéral, Emmanuel Delelis, Olivier Parissi, Vincent Simon, Aurélie Ruff, Marc Benarous, Richard Emiliani, Stéphane

Published in Retrovirology

BackgroundIntegration of human immunodeficiency virus type 1 (HIV-1) into a host cell chromosome is an essential step under the control of the viral integrase (IN). Although this enzyme is necessary and sufficient to catalyze the integration reaction in vitro, cellular cofactors are involved in the process in vivo. The chromatin-associated factor L...

The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells.

Lefevre, Sophie Sliwa, Dominika Auchère, Françoise Brossas, Caroline Ruckenstuhl, Christoph Boggetto, Nicole Lesuisse, Emmanuel Madeo, Frank Camadro, Jean-Michel Santos, Renata ...

Friedreich ataxia is the most common recessive neurodegenerative disease and is caused by reduced expression of mitochondrial frataxin. Frataxin depletion causes impairment in iron-sulfur cluster and heme biosynthesis, disruption of iron homeostasis and hypersensitivity to oxidants. Currently no pharmacological treatment blocks disease progression,...

Genetics for understanding and predicting clinical progression in multiple sclerosis.

Depaz, R Granger, B Cournu-Rebeix, I Bouafia, A Fontaine, B

Published in Revue neurologique

Multiple sclerosis (MS) is a dys-immune disease of the central nervous system with highly variable and unpredictable long-term outcome. In the early 1970s association between HLA alleles and MS was established. Very recently, the power of Genome Wide Association Studies (GWAS) enabled the identification of several loci involved in immune functions ...

Sperm Methylation Profiles Reveal Features of Epigenetic Inheritance and Evolution in Primates PDF available through Get Fulltext Research

Published in Cell

Structure-function relationships of CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter b...

Catel-Ferreira, Manuella Coadou, Gaël Molle, Virginie Mugnier, Pauline Nordmann, Patrice Siroy, Axel Jouenne, Thierry Dé, Emmanuelle

OBJECTIVES: In the context of the increasing worldwide occurrence of imipenem-resistant Acinetobacter baumannii strains, we investigated a possible porin-mediated mechanism relating to the carbapenem resistance-associated outer membrane protein, CarO. The aim of this study was to determine whether this porin may be a diffusion pathway for carbapene...

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

Guenin-Mace, L. Carrette, F. Asperti-Boursin, F. Le Bon, A. Caleechurn, L. Di Bartolo, V. Fontanet, A. Bismuth, G. Demangel, C.

Published in Proc Natl Acad Sci U S A

Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. PDF available through Get Fulltext Research

Liu, Luyan Okada, Satoshi Kong, Xiao-Fei Kreins, Alexandra Y Cypowyj, Sophie Abhyankar, Avinash Toubiana, Julie Itan, Yuval Audry, Magali Nitschke, Patrick ...

Published in The Journal of experimental medicine

Chronic mucocutaneous candidiasis disease (CMCD) may be caused by autosomal dominant (AD) IL-17F deficiency or autosomal recessive (AR) IL-17RA deficiency. Here, using whole-exome sequencing, we identified heterozygous germline mutations in STAT1 in 47 patients from 20 kindreds with AD CMCD. Previously described heterozygous STAT1 mutant alleles ar...

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