Ecole Doctorale Complexité du Vivant - UPMC
  • Upload

  • Log in

  • Sign up

Search on MyScienceWork
13 News 174 Publications 485 Members 2 Events

3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition ...

Toledano, Elie Ogryzko, Vasily Danchin, Antoine Ladant, Daniel Mechold, Undine

pAp (3'-5' phosphoadenosine phosphate) is a by-product of sulfur and lipid metabolism and has been shown to have strong inhibitory properties on RNA catabolism. In the present paper we report a new target of pAp, PARP-1 [poly(ADP-ribose) polymerase 1], a key enzyme in the detection of DNA single-strand breaks. We show that pAp can interact with PAR...

Effect of locomotor training on muscle performance in the context of nerve-muscle communication dysfunction

Hadj-Said, Wahiba Bangratz, Marie Vignaud, Alban Chatonnet, Arnaud Butler-Browne, Gillian Nicole, Sophie Agbulut, Onnick Ferry, Arnaud

Introduction: The effects of locomotor training (LT) on skeletal muscle after peripheral nerve injury and acetylcholinesterase deficiency are not well documented. Methods: We determined the effects of LT on mouse soleus muscle performance after sciatic nerve transection with excision (full and permanent denervation), nerve transection (partial func...

Secretome of human bronchial epithelial cells in response to the fungal pathogen Aspergillus fumigatus analyzed by diffe...

Fekkar, A Balloy, V Pionneau, C Marinach-Patrice, C Chignard, M Mazier, D

Published in The Journal of infectious diseases

For years, the analysis of innate responses to the major mold pathogen Aspergillus fumigatus has been restricted to specialized cells, such as professional phagocytes. More recently, the contribution of the airway epithelial barrier has been assessed and studies have shown that it was able to sense and react to the Aspergillus infection, for exampl...

Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells. PDF available through Get Fulltext Research

Warrick, Emilie Garcia, Marta Chagnoleau, Corinne Chevallier, Odile Bergoglio, Valérie Sartori, Daniela Mavilio, Fulvio Angulo, Jaime F Avril, Marie-Françoise Sarasin, Alain ...

Published in Molecular therapy : the journal of the American Society of Gene Therapy

Xeroderma pigmentosum (XP) is a devastating disease associated with dramatic skin cancer proneness. XP cells are deficient in nucleotide excision repair (NER) of bulky DNA adducts including ultraviolet (UV)-induced mutagenic lesions. Approaches of corrective gene transfer in NER-deficient keratinocyte stem cells hold great hope for the long-term tr...

Calpain activation by the Shigella flexneri effector VirA regulates key steps in the formation and life of the bacterium... PDF available through Get Fulltext Research

Bergounioux, Jean Elisee, Ruben Prunier, Anne-Laure Donnadieu, Françoise Sperandio, Brice Sansonetti, Philippe Arbibe, Laurence

Published in Cell host & microbe

The enteropathogen Shigella flexneri invades epithelial cells, leading to inflammation and tissue destruction. We report that Shigella infection of epithelial cells induces an early genotoxic stress, but the resulting p53 response and cell death are impaired due to the bacterium's ability to promote p53 degradation, mainly through calpain protease ...

Genome-wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non-syndromic familia...

Caburet, Sandrine Zavadakova, Petra Ben-Neriah, Ziva Bouhali, Kamal Dipietromaria, Aurélie Charon, Céline Besse, Céline Laissue, Paul Chalifa-Caspi, Vered Christin-Maitre, Sophie ...

Published in PloS one

The human condition known as Premature Ovarian Failure (POF) is characterized by loss of ovarian function before the age of 40. A majority of POF cases are sporadic, but 10-15% are familial, suggesting a genetic origin of the disease. Although several causal mutations have been identified, the etiology of POF is still unknown for about 90% of the p...

Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency.

Gineau, Laure Cognet, Céline Kara, Nihan Lach, Francis Peter Dunne, Jean Veturi, Uma Picard, Capucine Trouillet, Céline Eidenschenk, Céline Aoufouchi, Said ...

Natural killer (NK) cells are circulating cytotoxic lymphocytes that exert potent and nonredundant antiviral activity and antitumoral activity in the mouse; however, their function in host defense in humans remains unclear. Here, we investigated 6 related patients with autosomal recessive growth retardation, adrenal insufficiency, and a selective N...

Fungal-induced cell cycle impairment, chromosome instability and apoptosis via differential activation of NF-κB.

Ben-Abdallah, Mariem Sturny-Leclère, Aude Avé, Patrick Louise, Anne Moyrand, Frédérique Weih, Falk Janbon, Guilhem Mémet, Sylvie

Published in PLoS pathogens

Microbial pathogens have developed efficient strategies to compromise host immune responses. Cryptococcus neoformans is a facultative intracellular pathogen, recognised as the most common cause of systemic fungal infections leading to severe meningoencephalitis, mainly in immunocompromised patients. This yeast is characterized by a polysaccharide c...

Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape

Chouaib, Salem Messai, Yosra Couve, Sophie Escudier, Bernard Hasmim, Meriem Noman, Muhammad Zaeem

Published in Frontiers in Immunology

Despite the impressive progress over the past decade, in the field of tumor immunology, such as the identification of tumor antigens and antigenic peptides, there are still many obstacles in eliciting an effective immune response to eradicate cancer. It has become increasingly clear that tumor microenvironment plays a crucial role in the control of...

Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells.

Sophie Lefevre Dominika Sliwa Pierre Rustin Jean-Michel Camadro Renata Santos

Published in Biochemical and Biophysical Research Communications

Friedreich ataxia (FA) is the most common recessive neurodegenerative disease. It is caused by deficiency in mitochondrial frataxin, which participates in iron-sulfur cluster assembly. Yeast cells lacking frataxin (Δyfh1 mutant) showed an increased proportion of fragmented mitochondria compared to wild-type. In addition, oxidative stress induced co...

  • ← Previous
  • 1
  • 2
  • 3
  • 4 (current)
  • 5
  • 6
  • …
  • 17
  • Next →
Powered by Polaris
  • FAQ