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13 News 174 Publications 485 Members 2 Events

PPARγ contributes to PKM2 and HK2 expression in fatty liver

Panasyuk, Ganna Espeillac, Catherine Chauvin, Céline Pradelli, Ludivine A. Horie, Yasuo Suzuki, Akira Annicotte, Jean-Sebastien Fajas, Lluis Foretz, Marc Verdeguer, Francisco ...

Published in Nature Communications

Rapidly proliferating cells promote glycolysis in aerobic conditions, to increase growth rate. Expression of specific glycolytic enzymes, namely pyruvate kinase M2 and hexokinase 2, concurs to this metabolic adaptation, as their kinetics and intracellular localization favour biosynthetic processes required for cell proliferation. Intracellular fact...

Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

Cossec, Jack-Christophe Lavaur, Jeremie Berman, Diego Rivals, Isabelle Hoischen, Alexander Stora, Samantha Ripoll, Clémentine Mircher, Clotilde Grattau, Yann OlivoMarin, Jean-Christophe ...

Enlarged early endosomes have been observed in neurons and fibroblasts in Down syndrome (DS). These endosome abnormalities have been implicated in the early development of Alzheimer's disease (AD) pathology in these subjects. Here, we show the presence of enlarged endosomes in blood mononuclear cells and lymphoblastoid cell lines (LCLs) from indivi...

Mendelian susceptibility to mycobacterial disease in egyptian children.

Nermeen Galal Jeannette Boutros Aisha Marsafy Xiao-Fei Kong Jacqueline Feinberg Jean-Laurent Casanova Stéphanie Boisson-Dupuis Jacinta Bustamante

Published in Mediterranean Journal of Hematology and Infectious Diseases

Tuberculosis remains a major health problem in developing countries especially with the emergence of multidrug resistant strains. Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a rare disorder with impaired immunity against mycobacterial pathogens. Reported MSMD etiologies highlight the crucial role of the Interferon gamma /Interleukin...

A Mouse Model of Schwartz-Jampel Syndrome Reveals Myelinating Schwann Cell Dysfunction with Persistent Axonal Depolariza...

Bangratz, Marie Sarrazin, Nadège Devaux, Jérôme Zambroni, Désirée Echaniz-Laguna, Andoni René, Frédérique Boërio, Delphine Davoine, Claire-Sophie Fontaine, Bertrand Feltri, Maria Laura ...

Published in The American Journal of Pathology

Congenital peripheral nerve hyperexcitability (PNH) is usually associated with impaired function of voltage-gated K+ channels (VGKCs) in neuromyotonia and demyelination in peripheral neuropathies. Schwartz-Jampel syndrome (SJS) is a form of PNH that is due to hypomorphic mutations of perlecan, the major proteoglycan of basement membranes. Schwann c...

DIGE enables the detection of a putative serum biomarker of fungal origin in a mouse model of invasive aspergillosis

Fekkar, A. Pionneau, C. Brossas, J.Y. Marinach-Patrice, C. Snounou, G. Brock, M. Ibrahim-Granet, O. Mazier, D.

Invasive aspergillosis (IA) is a major threat for immunocompromised patients. Diagnostic difficulties often delay specific treatment initiation, which increases mortality. Finding new biomarkers to improve and speed accurate diagnosis is thus vital. To investigate the ability of proteomic methods for discovering new biomarkers of IA, we used a DIGE...

Regulation of epithelial polarity by the E3 ubiquitin ligase Neuralized and the Bearded inhibitors in Drosophila.

Chanet, Soline Schweisguth, François

Published in Nature cell biology

Understanding how epithelial polarity is established and regulated during tissue morphogenesis is a major issue. Here, we identify a regulatory mechanism important for mesoderm invagination, germ-band extension and transepithelial migration in the Drosophila melanogaster embryo. This mechanism involves the inhibition of the conserved E3 ubiquitin l...

3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition ...

Toledano, Elie Ogryzko, Vasily Danchin, Antoine Ladant, Daniel Mechold, Undine

pAp (3'-5' phosphoadenosine phosphate) is a by-product of sulfur and lipid metabolism and has been shown to have strong inhibitory properties on RNA catabolism. In the present paper we report a new target of pAp, PARP-1 [poly(ADP-ribose) polymerase 1], a key enzyme in the detection of DNA single-strand breaks. We show that pAp can interact with PAR...

Effect of locomotor training on muscle performance in the context of nerve-muscle communication dysfunction

Hadj-Said, Wahiba Bangratz, Marie Vignaud, Alban Chatonnet, Arnaud Butler-Browne, Gillian Nicole, Sophie Agbulut, Onnick Ferry, Arnaud

Introduction: The effects of locomotor training (LT) on skeletal muscle after peripheral nerve injury and acetylcholinesterase deficiency are not well documented. Methods: We determined the effects of LT on mouse soleus muscle performance after sciatic nerve transection with excision (full and permanent denervation), nerve transection (partial func...

Secretome of human bronchial epithelial cells in response to the fungal pathogen Aspergillus fumigatus analyzed by diffe...

Fekkar, A Balloy, V Pionneau, C Marinach-Patrice, C Chignard, M Mazier, D

Published in The Journal of infectious diseases

For years, the analysis of innate responses to the major mold pathogen Aspergillus fumigatus has been restricted to specialized cells, such as professional phagocytes. More recently, the contribution of the airway epithelial barrier has been assessed and studies have shown that it was able to sense and react to the Aspergillus infection, for exampl...

Preclinical corrective gene transfer in xeroderma pigmentosum human skin stem cells.

Warrick, Emilie Garcia, Marta Chagnoleau, Corinne Chevallier, Odile Bergoglio, Valérie Sartori, Daniela Mavilio, Fulvio Angulo, Jaime F Avril, Marie-Françoise Sarasin, Alain ...

Published in Molecular therapy : the journal of the American Society of Gene Therapy

Xeroderma pigmentosum (XP) is a devastating disease associated with dramatic skin cancer proneness. XP cells are deficient in nucleotide excision repair (NER) of bulky DNA adducts including ultraviolet (UV)-induced mutagenic lesions. Approaches of corrective gene transfer in NER-deficient keratinocyte stem cells hold great hope for the long-term tr...

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