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13 News 174 Publications 485 Members 2 Events

BMP signaling controls muscle mass.

Sartori, Roberta Schirwis, Elija Blaauw, Bert Bortolanza, Sergia Zhao, Jinghui Enzo, Elena Stantzou, Amalia Mouisel, Etienne Toniolo, Luana Ferry, Arnaud ...

Published in Nature genetics

Cell size is determined by the balance between protein synthesis and degradation. This equilibrium is affected by hormones, nutrients, energy levels, mechanical stress and cytokines. Mutations that inactivate myostatin lead to excessive muscle growth in animals and humans, but the signals and pathways responsible for this hypertrophy remain largely...

Intravenous Gammaglobulin Inhibits Encephalitogenic Potential of Pathogenic T Cells and Interferes with their Traffickin...

Published in The Journal of Immunology

HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components a...

Published in Development

The nephron is a highly specialised segmented structure that provides essential filtration and resorption renal functions. It arises by formation of a polarised renal vesicle that differentiates into a comma-shaped body and then a regionalised S-shaped body (SSB), with the main prospective segments mapped to discrete domains. The regulatory circuit...

Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons

Brown, Guy C. Neher, Jonas J.

Published in Molecular Neurobiology

Inflammatory neurodegeneration contributes to a wide variety of brain pathologies. A number of mechanisms by which inflammatory-activated microglia and astrocytes kill neurons have been identified in culture. These include: (1) acute activation of the phagocyte NADPH oxidase (PHOX) found in microglia, (2) expression of the inducible nitric oxide sy...

Double Myod and Igf2 inactivation promotes brown adipose tissue development by increasing Prdm16 expression

Borensztein, M. Viengchareun, S. Montarras, D. Journot, L. Binart, N. Lombes, M. Dandolo, L.

Published in FASEB J

Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

C. P. El-Haibi G. W. Bell J. Zhang A. Y. Collmann D. Wood C. M. Scherber E. Csizmadia O. Mariani C. Zhu Antoine Campagne ...

Published in Proceedings of the National Academy of Sciences

Mesenchymal stem cells (MSCs) are multipotent progenitor cells with the ability to differentiate into multiple mesoderm lineages in the course of normal tissue homeostasis or during injury. We have previously shown that MSCs migrate to sites of tumorigenesis, where they become activated by cancer cells to promote metastasis. However, the molecular ...

A Comparative Study of Iron Uptake Mechanisms in Marine Microalgae: Iron Binding at the Cell Surface Is a Critical Step

Published in PLANT PHYSIOLOGY

We investigated iron uptake mechanisms in five marine microalgae from different ecologically important phyla: the diatoms Phaeodactylum tricornutum and Thalassiosira pseudonana, the prasinophyceae Ostreococcus tauri and Micromonas pusilla, and the coccolithophore Emiliania huxleyi. Among these species, only the two diatoms were clearly able to redu...

Selenoprotein N in skeletal muscle: from diseases to function

Castets, Perrine Lescure, Alain Guicheney, Pascale Allamand, Valérie

Published in Journal of Molecular Medicine

Selenoprotein N (SelN) deficiency causes several inherited neuromuscular disorders collectively termed SEPN1-related myopathies, characterized by early onset, generalized muscle atrophy, and muscle weakness affecting especially axial muscles and leading to spine rigidity, severe scoliosis, and respiratory insufficiency. SelN is ubiquitously express...

Effect of IVIg on human dendritic cell-mediated antigen uptake and presentation: role of lipid accumulation.

Othy, Shivashankar Bruneval, Patrick Topçu, Selma Dugail, Isabelle Delers, Francisco Lacroix-Desmazes, Sebastien Bayry, Jagadeesh Kaveri, Srini V

Published in Journal of autoimmunity

Intravenous immunoglobulin (IVIg) is a therapeutic preparation consisting of pools of normal, polyspecific IgG antibodies obtained from plasma of several thousand healthy individuals. In addition to its use in primary and secondary immune deficiency, IVIg is increasingly used in the therapy of a large number of autoimmune conditions. Despite its su...

Dominant-negative STAT1 SH2 domain mutations in unrelated patients with Mendelian susceptibility to mycobacterial diseas... PDF available through Get Fulltext Research

Tsumura, Miyuki Okada, Satoshi Sakai, Hidemasa Yasunaga, Shin'ichiro Ohtsubo, Motoaki Murata, Takuji Obata, Hideto Yasumi, Takahiro Kong, Xiao-Fei Abhyankar, Avinash ...

Published in Human mutation

Patients carrying two loss-of-function (or hypomorphic) alleles of STAT1 are vulnerable to intracellular bacterial and viral diseases. Heterozygosity for loss-of-function dominant-negative mutations in STAT1 is responsible for autosomal dominant (AD) Mendelian susceptibility to mycobacterial disease (MSMD), whereas heterozygosity for gain-of-functi...

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