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Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors....

Tihana Jovanic Benjamin Roche Géraldine Attal-Bonnefoy Olivier Leclercq François Rougeon

Somatic hypermutation (SHM) of immunoglobulin genes is currently viewed as a two step process initiated by the deamination of deoxycytidine (C) to deoxyuridine (U), catalysed by the activation induced deaminase (AID). Phase 1 mutations arise from DNA replication across the uracil residue or the abasic site, generated by the uracil-DNA glycosylase, ...

Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.

Katrin Daniel Julian Lange Khaled Hached Jun Fu Konstantinos Anastassiadis Ignasi Roig Howard J Cooke A Francis Stewart Katja Wassmann Maria Jasin ...

Meiotic crossover formation between homologous chromosomes (homologues) entails DNA double-strand break (DSB) formation, homology search using DSB ends, and synaptonemal-complex formation coupled with DSB repair. Meiotic progression must be prevented until DSB repair and homologue alignment are completed, to avoid the formation of aneuploid gametes...

A novel primary immunodeficiency with specific natural-killer cell deficiency maps to the centromeric region of chromoso...

Celine Eidenschenk Jean Dunne Emmanuelle Jouanguy Claire Fourlinnie Laure Gineau Delphine Bacq Corrina McMahon Owen Smith Jean-Laurent Casanova Laurent Abel ...

We describe four children with a novel primary immunodeficiency consisting of specific natural-killer (NK) cell deficiency and susceptibility to viral diseases. One child developed an Epstein-Barr virus-driven lymphoproliferative disorder; two others developed severe respiratory illnesses of probable viral etiology. The four patients are related an...

FOXO1, T-cell trafficking and immune responses.

Florent Carrette Stéphanie Fabre Georges Bismuth

Efficient T-cell adaptive immune response require a faultless coordination between migration of naive T-cells into secondary lymphoid organs and critical biological outcomes driven by antigen such as cell division and cell differentiation into effector and memory cells. Recent works have shown that the phosphoinositide 3-kinase (PI3K) pathway could...

Stepwise release of biologically active HMGB1 during HSV-2 infection.

Chloé Borde Stéphanie Barnay-Verdier Claire Gaillard Hakim Hocini Vincent Maréchal Joël Gozlan

High mobility group box 1 protein (HMGB1) is a major endogenous danger signal that triggers inflammation and immunity during septic and aseptic stresses. HMGB1 recently emerged as a key soluble factor in the pathogenesis of various infectious diseases, but nothing is known of its behaviour during herpesvirus infection. We therefore investigated the...

Oxidative stress resistance in Deinococcus radiodurans. PDF available through Get Fulltext Research

Dea Slade Miroslav Radman

Deinococcus radiodurans is a robust bacterium best known for its capacity to repair massive DNA damage efficiently and accurately. It is extremely resistant to many DNA-damaging agents, including ionizing radiation and UV radiation (100 to 295 nm), desiccation, and mitomycin C, which induce oxidative damage not only to DNA but also to all cellular ...

Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 sub...

Nicolas Richet-Tiuilliere

Published in Nucleic Acids Research

BMP signaling controls muscle mass

Roberta Sartori Elja Schirwis Bert Blaauw Sergia Bortolanza Jinghui Zhao Elena Enzo Amalia Stantzou Etienne Mouisel Luana Toniolo Arnaud Ferry ...

Published in Nature Genetics

Paternal uniparental isodisomy of chromosome 6 causing a complex syndrome including complete IFN-gamma receptor 1 defici...

Carolina Prando Stéphanie Boisson-Dupuis Audrey V Grant Xiao-Fei Kong Jacinta Bustamante Jacqueline Feinberg Ariane Chapgier Yoann Rose Lucile Jannière Elena Rizzardi ...

Mendelian susceptibility to mycobacterial disease (MSMD) is a rare primary immunodeficiency associated with clinical disease caused by weakly virulent mycobacterial species. Interferon gamma receptor 1 (IFN-gammaR1) deficiency is a genetic etiology of MSMD. We describe the clinical and genetic features of a 7-year-old Italian boy suffering from MSM...

Smad4/DPC4: a Barrier against Tumor Progression driven by RTK/Ras/Erk and Wnt/GSK3 signaling PDF available through Get Fulltext Research

Hadrien Demagny

Published in Molecular & Cellular Oncology

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