Published in Digital Biomarkers
We conducted a pilot study using a passive radio-wave-based home monitor in individuals with Parkinson disease (PD) with a focus on gait, home activity, and time in bed. We enrolled 7 ambulatory individuals to have the device installed in the bedroom of their homes over 8 weeks and performed standard PD assessments at baseline. We evaluated the abi...
Published in Journal of High Energy Physics
Processes producing a charged final state at the LHC most often have a positive or null integral charge asymmetry. We propose a novel method for an indirect measurement of the mass of these final states based upon the process integral charge asymmetry. We present this method in three stages. Firstly, the theoretical prediction of the integral charg...
Published in Human Studies
Born in the 17th century, journal peer review is an extremely diverse technology, constantly torn between two often incompatible goals: the validation of manuscripts conceived as a collective industrial-like reproducible process performed to assert scientific statements, and the dissemination of articles considered as a means to spur scientific dis...
Published in Case Reports in Neurology
In 2012, a 50 year-old athletic male presented with weakness, pain and unilateral phrenic paralysis, followed by bilateral phrenic paralysis with deep dyspnea. In 2013, the Parsonage-Turner syndrome was diagnosed. When the patient was seen in September 2014 for the first time, he was facing phrenic neuromuscular failure, which led to the hypothesis...
Published in Molecular Therapy — Methods & Clinical Development
Published in Nature communications
Cell mechanics control the outcome of cell division. In mitosis, external forces applied on a stiff cortex direct spindle orientation and morphogenesis. During oocyte meiosis on the contrary, spindle positioning depends on cortex softening. How changes in cortical organization induce cortex softening has not yet been addressed. Furthermore, the ran...
International audience
Published in Development
A central question in development is to define how the equilibrium between cell proliferation and differentiation is temporally and spatially regulated during tissue formation. Here, we address how interactions between cyclin-dependent kinase inhibitors essential for myogenic growth arrest (p21 cip1 and p57 kip2), the Notch pathway and myogenic reg...
Published in Cellular and Molecular Life Sciences
Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of multiple birth defects. The drug is now used in the treatment of leprosy and multiple myeloma. However, its use is limited due to its potent teratogenic activity. The mechanism by which thalidomide causes limb malformations and other developmental defects is a ...
Published in Virology Journal
RVF live attenuated vaccine (Smithburn strain) was evaluated by using goats as experimental animal. The results indicate that this vaccine cause severe deleterious pathological changes in liver especially in kids and causing abortion in pregnant does. The virus was seen to be propagated inside hepatic cells forming intranuclear inclusions which was...
